Key Publications

Mediator kinase inhibition suppresses in vivo growth and prevents drug resistance in triple-negative breast cancer X. Ding et al., Proc. Natl. Acad. Sci. USA 121 (47) e2414501121 (2024) https://www.pnas.org/doi/10.1073/pnas.2414501121.
Mediator kinase inhibition reverses castration resistance of advanced prostate cancer J. Li et al., J Clin Invest. 134(10):e176709 (2024). https://www.jci.org/articles/view/176709.
Mediator kinase plays a key role in transcriptional reprogramming M. Chen et al. Proc. Natl. Acad. Sci. USA 114, 10208-10213 (2017)https://www.pnas.org/doi/full/10.1073/pnas.1710467114.
Both CDK8 and CDK19 Mediator kinases regulate transcriptional reprogramming induced by different signals M. Chen et al., Nucleic Acids Research, 51, 7288-7313 (2023)https://academic.oup.com/nar/article/51/14/7288/7209341.
The outcome of therapy in several types of cancer is impacted by Mediator kinase I. B. Roninson et al. Cells 8, 821 (2019)https://www.mdpi.com/2073-4409/8/8/821.
Inhibition of Mediator kinase suppresses adverse effects of chemotherapy on tumor growth D. C. Porter et al. Proc. Natl. Acad. Sci. USA 109, 13799-13804 (2012)https://www.pnas.org/doi/10.1073/pnas.1206906109.
Mediator kinase inhibition prevents the development of drug resistance A. C. Sharko et al. Cells 10, 144 (2021)https://www.mdpi.com/2073-4409/10/1/144.
Mediator kinase inhibition suppresses the growth of breast cancer and improves hormone therapy M. S. McDermott et al. Oncotarget 8, 12558-12575 (2017)https://www.oncotarget.com/article/14894/text/.
Mediator kinase inhibition suppresses metastatic growth of colon cancer in the liver J. Liang et al. Cancer Res 78, 6594-6606 (2018)https://aacrjournals.org/cancerres/article/78/23/6594/543864.
Mediator kinase inhibition suppresses HER2-positive breast cancers and overcomes resistance to HER2-targeting drugs X. Ding et al., Proc. Natl. Acad. Sci. USA, 119, e2201073119 (2022)https://www.pnas.org/doi/10.1073/pnas.2201073119.
COPZ1 depletion selectively kills tumor cells, whether or not the cells are dividing M. Shtutman et al. Proc Natl. Acad. Sci, USA 108 12449-12454 (2011)https://www.pnas.org/doi/10.1073/pnas.1103842108.

Share this: